Download Antioxidants in Biology and Medicine: Essentials, Advances, by Professor and Chair Dr Yunbo Li PDF

By Professor and Chair Dr Yunbo Li

This can be a publication that takes a special method of integrating wisdom in antioxidants from necessities to advances, and from simple study to medical purposes. This e-book provides clinical info on antioxidants in an organised, cogent, and in-depth demeanour. The constant layout of writing, the full-colour illustrations, and the excellent record of references make the publication available and fascinating. along with its price as a textbook for undergraduate and graduate scholars in lifestyles technological know-how, "Antioxidants in Biology and medication" can be an invaluable reference for biomedical examine scientists, clinicians, and different wellbeing and fitness execs.

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Extra info for Antioxidants in Biology and Medicine: Essentials, Advances, and Clinical Applications

Sample text

4 of Chapter 1, reactive aldehydes are produced from lipid peroxidation elicited by ROS/RNS, and they can cause damage to biomolecules. 2. Genetic Manipulations of Antioxidants Transgenic overexpression or knockout of particular antioxidant genes is frequently used to study the biological activities of endogenous antioxidant proteins in experimental animals. While these genetic animal models provide the most convincing evidence regarding the biological functions of particular antioxidant proteins, interpretation of the data should be done with caution.

Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of agedependent skeletal muscle atrophy. Free Radic. Biol. Med. 2006;40:1993-2004. [41] Bivalacqua TJ, Armstrong JS, Biggerstaff J, Abdel-Mageed AB, Kadowitz PJ, Hellstrom WJ, et al. Gene transfer of extracellular SOD to the penis reduces O2-. and Superoxide Dismutase [42] [43] [44] [45] [46] [47] [48] [49] [50] [51] [52] [53] 45 improves erectile function in aged rats. Am. J. Physiol. Heart Circ. Physiol. 2003;284: H1408-1421.

Oral coadministration of Cu,ZnSOD and catalase is reported to attenuate stress-induced gastric mucosal lesions in rats. In an animal model of chemically-induced acute colitis, transgenic overexpression of Cu,ZnSOD results in amelioration of colonic inflammation and improves animal survival [28]. 7. Role in Renal Diseases Either viral vector-mediated or transgenic overexpression of SODs is reported to attenuate renal ischemia-reperfusion injury in animal models. Administration of lecithinized SOD reduces ischemia-induced chronic allograft dysfunction in rats.

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