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296, 1110-1114. 3. F. S. (1988) Therapeutic drug monitoring. Clin. Pharmacol. Ther. 43, 345-353. 4. Richens, A. & Marks, V. (1981) Therapeutic drug monitoring, Churchill Livingston, Edinburgh. 5. Gal, P. (1988) Therapeutic drug monitoring in neonates: problems and issues. Drug Intell. Clin. Pharm. 22, 317-323. 6. A. (1991) Knowledge, attitude and practice in antiepileptic drug monitoring. Acta Neurol. Scand. Supplementum 134,«, pp. 69-96, 97-122. 7. E. (1981) The clinical interpretation and application of drug concentration data.

As stated in an accompanying editorial (101), questions still requiring answers include: is there justification for partial or relative drug withdrawal in some patients, can one remain seizure free while a "sub-therapeutic" dose is being used in an attempt to minimize toxicity and do the seizure threshold and minimal therapeutic drug level decline with an increased duration of effective seizure control? Discontinuation of drug treatment holds promise in many respects for the patients involved but does complicate the interpretation of the role (if any) of TDM in this population.

77, 221-227. 23. F. B. (1982) Simultaneous determination of amitriptyline, nortriptyline and their respective isomeric 10-hydroxy metabolites in plasma by liquid chromatography. J. Chromatogr. 230, 391 -400. 24. , Gray, S. & Jatlow, P. (1982) Steady state plasma concentrations of cis- and trans-10-OH amitriptyline metabolities. Clin. Pharmacol. Ther. 31, 609-616. 25. Fräser, A. D. & Isner, A. F. (1988) Optimal drug monitoring of carbamazepine by routine analysis of carbamazepine and carbamazepine 10,11-epoxide.

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