By Shayne C. Gad
Acute toxicology trying out offers the 1st defensive position opposed to almost certainly risky chemical substances. This e-book is a whole and useful consultant to undertaking and reading all regulatory required and popular acute toxicity assessments. It offers certain protocols for the entire universal attempt designs and experiences their improvement and ambitions. Acute Toxicology checking out, moment Edition will curiosity not just staff within the pharmaceutical undefined, but additionally researchers and scholars in toxicology and public health.
* Over a hundred tables summarizing and examining results
* entire insurance of all significant try out designs and their obstacles and advantages
* present prestige of different attempt designs and types
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Additional resources for Acute Toxicology Testing
5 ml of physiological saline. If the test substance is a liquid, a patch is applied and secured to the appropriate skin site. 5 ml of test substance to the patch. If the test substance is a fabric, a 1 • 1-in. square sample is cut and placed on a patch. The test substance patch is placed on the appropriate skin site and secured. 5 ml of physiological saline. ). The positive control substance and vehicle control substance are applied to a gauze patch in the same manner as a liquid test substance.
4. When a test substance produces dermal irritation that persists 72 hr postapplication, daily observations of test and control sites are continued on all animals until all irritation caused by the test substance resolves or until Day 14 postapplication. D. Evaluation of results 1. A subtotal irritation value for erythema or eschar formation is determined for each rabbit by adding the values observed at 25, 48, and 72 hr postapplication. 2. A subtotal irritation value for edema formation is determined for each rabbit by adding the values observed at 25, 48, and 72 hr postapplication.
The collar remains in place for the 24-hr exposure period. The collars are utilized to prevent removal of wrappings and patches by the animals, while allowing the animals food and water ad libitum. The wrapping is removed at the end of the 24-hr exposure period. The test substance skin site is wiped to remove any test substance still remaining. When colored test substances (such as dyes) are used, it may be necessary to wash the test substance from the test site with an appropriate solvent or vehicle (one that is suitable for the substance being tested).