By H. Rahn (auth.), Hermann Rahn Ph.D., Omar Prakash M.D. (eds.)
During the final twenty years teams of investigators have involved themselves with the matter of acid-base rules at a number of physique temperatures. each one workforce, in specialist isolation, pursued a separate course. Surgeons and anesthe tists constructed strategies and instruments for hypothermic cardio-pulmonary by-pass operations and established their purpose for acid-base administration on in vitro types of blood habit. Physiologists and biochemists, nonetheless, endeavored to appreciate acid-base legislation in dwelling organisms certainly subjected to adjustments in physique temperature. simply within the final decade has there been an expanding know-how that every workforce may benefit from the other's stories. With this target in brain participants of either teams have been invited to give their perspectives and observations within the desire of arriving at a greater figuring out of acid-base administration in the course of hypothermia and gaining a better perception into the standards which keep watch over acid-base legislation in the course of normothermia. This resulted in the presen tation of the current quantity with the purpose of offering the clinician with a survey of current theories and the ensuing concepts for administration of the hypother mic sufferer. Acknowledgment The editors convey their nice appreciation to overlook Augusta Dustan for her committed attempt within the instruction and enhancing of the manuscripts. participants Heinz Becker, M. D. division of surgical procedure, college of California clinical middle, Los An geles, l. a., CA 90024, U. S. A. Gerald D. Buckberg, M. D. division of surgical procedure, college of California clinical middle, Los An geles, CA 90024, U. S. A.
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9. Heller HC, Walker GM, Florant GL, Glotzbach SF, Berger Rl: Sleep and hibernation: Electrophysiological and thermoregulatory homologies. In: Strategies in Cold: Natural Torpidity and Thermogenesis, Wang LC, Hudson lW (eds). Academic Press, New York, 1978: 225-265. 10. Chatfield PO, Lyman CP: Subcortical electrical activity in the golden hamster during arousal from hibernation. Electroencephalogr Clin Neurophysiol 6: 403-408, 1954. 11. Kayser C, Malan A: Central nervous system and hibernation.
Intracellular acid-base regulation If acid-base regulation subserves the preservation of ionization state of protein histidyl imidazole groups, the ultimate focus of all acid-base regulation must be directed toward the intracellular compartment, the principal site of protein enzymatic activity. The linkage between intracellular and extracellular acid-base regulation is not as yet well understood as it must operate in vivo. Experimental studies have for analytial convenience tended to uncouple the two phases.
COC) A. 7) 73 70 B. NORMOTHERMIC Hedgehog * Malan, unpublished 30 72 39 mammals. It is therefore quite recent in terms of biochemical evolution, so that only slight changes may have occurred at the molecular level. There should be no fundamental difference in the general biochemical organization of hibernators compared to other mammals and to reptiles. This applies to the buffers and to the acid-base regulating systems in general. Thus the pH and P CO2 vs. temperature relationships of blood in vitro are the same as those described by Reeves (Chapter 2) in ectothermic, nonhibernating mammals .